The underlying metabolic cause of many different common diseases.

Most, if not all, common chronic disease states, whilst appearing to be very different outwardly, have the same underlying cause – that of a ‘failed energy system’.  Over time, the ageing process contributes to a progressive decline in mitochondrial function, leaving our bodies in a metabolically compromised state with mitochondrial insufficiency.  Dr Georgia Ede has the following to say concerning the process of cellular degeneration:

‘Normal cells use the sophisticated process of respiration to efficiently turn any kind of nutrient (fat, carbohydrate or protein), into high amounts of energy.  This process requires oxygen and breaks down completely into harmless carbon dioxide and water.  Cells which are damaged use a primitive process called ‘fermentation’ to inefficiently turn either glucose (primarily from carbohydrates) of the amino acid glutamine (from protein), into small quantities of of energy (note that fats cannot be fermented).  This process does not require oxygen, and only partially breaks down food molecules into lactic acid and ammonia, which are toxic waste products.’

How do damaged mitochondria switch from respiration to fermentation?

‘Mitochondria evolved a process called the retrograde response, which helps them deal with temporary stress or damage.  It is called a retrograde (backwards) response because under normal circumstances, the DNA inside the nucleus calls the shots and sends orders out to the mitochondria in the cytoplasm.  However, if a mitochondrian is damaged, and respiration is endangered, the mitochondrian sends an SOS message to the nucleus saying ‘We don’t have enough energy….we need to begin fermentation!’.  It essentially tells the nucleus to activate fermentation genes instead of respiration genes.  In essence, you can think of fermentation as a clunky back up generator to the normal process of respiration.’

Understanding our disease progression as a reflection of cellular energy decline provides the explanation of why modern medicine is failing in its treatment of many common chronic conditions.  It is futile to treat on a symptom based level, when the root cause of the disease is being ignored.  Whilst we appear very different from each other, and our ageing patterns vary in terms of the expression of chronic disease, at the cell level we are the same.

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